She was the daughter of Isabel Luisa Fernanda, the subject of a Subalbum earlier in this Album. Marie Isabelle lived during the Second Empire and Third Republic so she was not in a position to directly influence history. However, her daughter Amélie became Queen of Portugal while another daughter, Louise, is grandmother of former King Juan Carlos of Spain. Her daughters Amélie and Hélène are the subjects of later Subalbums. Her Wikipedia article is here.