There is a portrait of her husband described as "Gian Gerolamo Grumelli, Italian statesman and noble by Giovanni Battista Moroni." Isotta was a famous poet. She was married first to a member of the Spanish Aragon family, Lelio Secco d'Aragona, who died around 1560. She then married Gian Grumelli. A Google book, Shining Eyes, Cruel Fortune: The Lives and Loves of Italian Renaissance Women Poets, describes the turbulent life of her and her family as France and Spain fought over north Italy and assassination was an everyday fact of life for the elite.