She was portrayed several times during her life by Bronzino. The changes that occurred between 1550 and 1560 are stunning.
Her Wikipedia article is here.
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1556 Catherine de Medici possibly by Agnolo Bronzino
1527ca. Lady Mary Guildford by Hans Holbein the Younger (Kupferstichkabinett, Öffentliche Kunstsammlung, Basel)
1550 Eleonora de Toledo by Bronzino (Uffizi) face
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