Her Wikipedia article begins, "Isabella of Portugal (24 October 1503 – 1 May 1539) was an Infanta of Portugal, by birth, and a Holy Roman Empress, Queen of Germany, Italy, Spain, Naples and Sicily, Duchess of Burgundy etc. as the spouse of Charles V, Holy Roman Emperor. She was the daughter of Manuel I of Portugal and Maria of Aragon. She served as regent of Spain during the absence of her spouse for long periods..." One of her sons, Felipe became Felipe II, King of Spain, known in the anglophone world for launching the Spanish Armada against England in 1588.
Grand Ladies
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ca. 1555 Caterina de' Medici by ? (Galleria degli Uffizi - Firenze, Toscana, Italy)
ca. 1586 Isabel Clara Eugenia with Magdalena Ruiz by the studio of Alonso Sanchez Coello (Museo Nacional del Prado - Madrid, Spain)
Isabel de Portugal by ? (location unknown to gogm)
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