Her Wikipedia article begins, "Isabella of Portugal (24 October 1503 – 1 May 1539) was an Infanta of Portugal, by birth, and a Holy Roman Empress, Queen of Germany, Italy, Spain, Naples and Sicily, Duchess of Burgundy etc. as the spouse of Charles V, Holy Roman Emperor. She was the daughter of Manuel I of Portugal and Maria of Aragon. She served as regent of Spain during the absence of her spouse for long periods..." One of her sons, Felipe became Felipe II, King of Spain, known in the anglophone world for launching the Spanish Armada against England in 1588.